ISSN: 1678-9741 - Open Access

Volume 35 - Número 6


EDITORIAL
Healthcare Deprived Centers Attempting Congenital Heart Surgery: what is Desirable versus what is Attainable in this Covid Era?

Aubyn MarathI; Vinicius J S NinaII; Rachel Vilela de A Haickel NinaIII; Barbara FerdmanIV

Braz J Cardiovasc Surg 35; Publish in: 8/2/2025
Brazilian Academy of Cardiovascular Surgery: From Idea to Reality

José WanderleyI; Ênio BuffoloIII; José Teles de MendonçaIV

Braz J Cardiovasc Surg 35; Publish in: 8/2/2025

ORIGINAL ARTICLE
Impact of Preoperative Aspirin on Long-Term Outcomes in Diabetic Patients Following Coronary Artery Bypass Grafting: a Propensity Score Matched Study

Sleiman Sebastian Aboul-HassanI; Tomasz StankowskiII; Jakub MarczakIII; Maciej PeksaI; Marcin NawotkaI; Ryszard StanislawskiI; Lukasz MoskalIV; Adam LipowskiV; Michel Pompeu B. O. SáVI; Romuald CichonI

Braz J Cardiovasc Surg 35; Publish in: 8/2/2025
Introduction: This study aimed to determine the effect of preoperative aspirin administration on early and long-term clinical outcomes in patients suffering from diabetes mellitus (DM) undergoing coronary artery bypass grafting (CABG).
Methods: In this observational study, a total of 315 patients were included and grouped according to the time interval between their last aspirin dose and the time of surgery; patients who had been continued aspirin intake with last administered dose ≤ 24-hours before CABG (n=144) and those who had been given the last dose of aspirin between 24 to 48 hours before CABG (n=171).
Results: Multivariable analysis showed that the continuation of preoperative aspirin intake ≤ 24 hours before CABG in patients with DM is associated with reduced incidence of 30-day major adverse cardiac and cerebral events (MACCE) (P=0.004) as well as reduced incidence of composite 30-day mortality/MACCE (P=0.012). During mean follow-up of 37±17.5 months, the unadjusted hazard ratio (HR) showed that aspirin ≤ 24 hours prior CABG in patients with DM significantly reduced the incidence of MACCE and composite of mortality/MACCE during follow-up (HR: 0.50; 95% confidence interval [CI]: 0.29-0.87; P=0.014 and HR: 0.61; 95% CI: 0.38-0.97; P=0.039, respectively). However, after propensity score (PS) matching, the PS-adjusted HR showed a non-significant trend towards the reduction of MACCE during follow-up (HR: 0.58; 95% CI: 0.31-1.06; P=0.081).
Conclusion: Continuation of preoperative aspirin intake ≤ 24 hours before CABG in patients with DM is associated with reduced incidence of early MACCE, but without significant influence on long-term outcomes.
Keywords: Coronary artery bypass; Aspirin; Incidence; Propensity Score
Brazilian Single-Center Experience with Aortic Root Replacement in 448 Patients: What is the Best Technique?

Fabrício José DinatoI; Ricardo Ribeiro DiasI; José Augusto DuncanI; Fábio FernandesII; Félix José Álvares RamirezII; Charles MadyII; Fábio B JateneI

Braz J Cardiovasc Surg 35; Publish in: 8/2/2025
Introduction: The objective of this study was to evaluate whether a surgery with the use of valved conduit is capable of leading to better immediate and late results than those obtained by the valve-sparing aortic root reconstruction technique.
Methods: Between January 2002 and June 2016, 448 patients underwent aortic root reconstruction. These were divided into three groups according to the technique used: 319 (71.2%) patients received mechanical valved conduits, 49 (10.9%) received biological valved conduits, and 80 (17.9%) underwent the valve-sparing aortic root reconstruction technique. The results were examined by univariate and multivariate analyses of Cox proportional hazards models with multiple logistic regression.
Results: The hospital mortality rate was 7.5%. The mortality rates were 8.2%, 12%, and 2.5% in the mechanical valved conduit, biological valved conduit, and aortic valve-sparing groups, respectively, with no significant difference between groups (P=0.1). Thromboembolic complications and reoperation-free survival were also similar (P=0.169 and P=0.688). However, valve-sparing aortic root replacement was superior in terms of long-term survival (P<0.001), hemorrhagic-free survival (P<0.001), and endocarditis-free survival (P=0.048). Multivariate analysis showed that the following aspects had an impact on mortality: age > 70 years (P<0.001; hazard ratio [HR] 1.05), preoperative acute kidney injury (P<0.0042; HR 2.9), diagnosis of dissection (P<0.01; HR 2.0), previous cardiac surgery (P<0.027; HR 2.3), associated coronary artery bypass grafting (P<0.038; HR 1.8), reoperation for postoperative tamponade (P<0.004; HR 2.2) and postoperative acute kidney injury (P<0.02; HR 3.35).
Conclusion: Valve-sparing technique seems to be the operation of choice, whenever possible, for aortic root reconstruction.
Keywords: Aortic diseases; Thoracic; Cardiac surgical procedures; Aortic valve
Predictive Factors of Mortality in Acute Aortic Dissection and Validity of the EuroSCORE Algorithm in a Small-Sized Cardiac Surgery Institution

Facundo RiosI; Diego PerezI; Gerardo SocaI; Ricardo RobainaI; Victor DayanI

Braz J Cardiovasc Surg 35; Publish in: 8/2/2025
Introduction: Acute aortic dissection (AAD) is a devastating surgical emergency, with high operative mortality. Several scoring algorithms have been used to establish the expected mortality in these patients. Our objective was to define the predictive factors for mortality in our center and to validate the EuroSCORE and Penn classification system.
Methods: Patients who underwent surgery for AAD from 2006 to 2016 were retrieved from the institution’s database. Preoperative, operative and postoperative variables were collected. Observed and expected mortality was calculated by EuroSCORE. Logistic regression analysis and Cox regression analysis were performed to find predictors of operative mortality and survival, respectively. The receiver operating characteristic (ROC) curves were plotted for logistic EuroSCORE, and the area under the ROC curve (AUC) was calculated.
Results: 87 patients (27.6% female) underwent surgery for AAD. The mean age was 58.6±9.7 years. Expected and observed operative mortality was 25.8±15.1% and 20.7%, respectively. Penn Aa, Ab and Abc shared similar observed/expected (O/E) mortality ratio. The only independent predictor of operative mortality (OR: 3.63; 95% CI: 1.19-11.09) and survival (HR: 2.6; 95% CI: 1.5-4.8) was female gender. EuroSCORE showed a very poor prediction capacity, with an AUC=0.566.
Conclusion: Female gender was the only independent predictor of operative mortality and survival in our institution. EuroSCORE is a poor scoring algorithm to predict mortality in AAD, but with consistent results for Penn Aa, Ab and Abc.
Keywords: ROC Curve; Aneurysm; Dissecting; Postoperative Period; Coronary Artery Bypass
Predictors of Hospital Readmission within 30 Days after Coronary Artery Bypass Grafting: Data Analysis of 2,272 Brazilian Patients

Camilla do Rosário Nicolino ChiorinoI; Vinicius Batista SantosIII; Juliana de Lima LopesIII; Camila Takao LopesII

Braz J Cardiovasc Surg 35; Publish in: 8/2/2025
Introduction: In order to reduce readmission rates after coronary artery bypass grafting (CABG), its predictors should be known in different contexts. The objective of this study was to identify predictive factors of hospital readmission within 30 days after CABG in a Brazilian center.
Methods: A secondary analysis of an electronic database of patients submitted to isolated CABG was performed. The relationship between readmission within 30 days and demographic, anthropometric, clinical, and surgery-related characteristics was investigated by univariate analyses. Predictors were identified by multiple logistic regression.
Results: Data from 2,272 patients were included, with an incidence of readmission of 8.6%. The predictors of readmission were brown skin color (Beta=1.613; 95% confidence interval [CI] 1.047-2.458; P=0.030), African-American ethnicity (Beta=0.136; 95% CI 0.019-0.988; P=0.049), chronic kidney disease (Beta=2.214; 95% CI 1.269-3.865; P=0.005), postoperative use of blood products (Beta=1.515; 95% CI 1.101-2.086; P=0.011), chronic obstructive pulmonary disease (Beta=2.095; 95% CI 1.284-3.419; P=0.003), and use of acetylsalicylic acid (Beta=1.418; 95% CI 1.000-2.011; P=0.05). Preoperative antibiotic prophylaxis (Beta=0.742; 95% CI 0.5471.007; P=0.055) was marginally significant.
Conclusion: The predictors identified may support a closer postoperative follow-up and individualized planning for a safe discharge.
Keywords: Myocardial Revascularization; Risk Factors; Patient Readmission; Postoperative period
The New Surface Landmarks for Blind Axillary Vein Puncture

Yaming ShiI; Yongzhong ZongI

Braz J Cardiovasc Surg 35; Publish in: 8/2/2025
Objective: To compare the efficacy of blind axillary vein puncture utilizing the new surface landmarks for the subclavian method.
Methods: This prospective and randomized study was performed at two cardiology medical centers in East China. Five hundred thirty-eight patients indicated to undergo left-sided pacemaker or implantable cardioverter defibrillator implantation were enrolled, 272 patients under the axillary access and 266 patients under the subclavian approach. A new superficial landmark was used for the axillary venous approach, whereas conventional landmarks were used for the subclavian venous approach. We measured lead placement time and X-ray time from vein puncture until all leads were placed in superior vena cava. Meanwhile, the rate of success of lead placement and the type and incidence of complications were compared between the two groups.
Results: There were no significant differences between the two groups in baseline characteristics or number of leads implanted. There were high success rates for both strategies (98.6% [494/501] vs. 98.4% [479/487], P=0.752) and similar complication rates (14% [38/272] vs. 15% [40/266], P=0.702). Six cases in the control group developed subclavian venous crush syndrome and five had pneumothorax, while neither pneumothorax nor subclavian venous crush syndrome was observed in the experimental group.
Conclusion: We have developed a new blind approach to cannulate the axillary vein, which is as effective as the subclavian access, safer than that, and also allows to get this vein without the guidance of fluoroscopy, contrast, or echography.
Keywords: Axillary Vein; Vena Cava; Superior; X-Rays; Pneumothorax; Incidence; Control Groups; Crush Syndrome; Prospective Studies; Subclavian Vein; Pacemaker; Artificial
Frailty Significantly Associated with a Risk for Mid-term Outcomes in Elderly Chronic Coronary Syndrome Patients: a Prospective Study

Caglar OzmenI; Ali DenizI; İmam GünayI; İlker ÜnalII; Aziz Inan CelikIII; Çağlar Emre ÇağlıyanI; Onur Sinan DeveciI; Mesut DemirI; Mehmet KanadaşıI; Ayhan UsalI

Braz J Cardiovasc Surg 35; Publish in: 8/2/2025
Introduction: Frailty is a condition of elderly characterized by increased vulnerability to stressful events. Frail patients are more likely to have adverse events. The purposes of this study were to define frailty in patients aged ≥ 70 years with chronic coronary syndrome (CCS) and to evaluate mortality and prognostic significance of frailty in these patients.
Methods: We included 99 patients, ≥ 70 years old (mean age 74±5.3 years), with diagnosis of CCS. They were followed-up for up to 12 months. The frailty score was evaluated according to the Canadian Study of Health and Aging (CSHA). All patients were divided as frail or non-frail. The groups were compared for their characteristics and clinical outcomes.
Results: Fifty patients were classified as frail, and 49 patients as non-frail. The 12-month Major Adverse Cardiac Events (MACE) rate was 69.4% in frail patients and 20% in non-frail patients. Frailty increases the risk for MACE as much as 3.48 times. Two patients died in the non-frail group and 11 patients died in the frail group. Frailty increases the risk for death as much as 6.05 times. When we compared the aforementioned risk factors by multivariate analysis, higher CSHA frailty score was associated with increased MACE and death (relative risk [RR] = 22.94, 95% confidence interval [CI] 3.33-158.19, P=0.001, for MACE; RR = 7.41, 95% CI 1.44-38.03, P=0.016, for death).
Conclusion: Being a frail elderly CCS patient is associated with worse outcomes. Therefore, frailty score should be evaluated for elderly CCS patients as a prognostic marker.
Keywords: Frailty; Frail Elderly; Risk Factors; Confidence Intervals; Multivariate analysis; Prognosis; Canada; Aging; Death; Heart
Cardiac Output Values and Correlation of Renal Injury with Neutrophil Gelatinase-Associated Lipocalin Levels in Off-Pump Coronary Artery Bypass Patients

Şahin ŞahinalpI; Zeki TemiztürkII; Kadir ÇevikerIII; Kanat ÖzışıkIV; Uğursay KızıltepeV

Braz J Cardiovasc Surg 35; Publish in: 8/2/2025
Objective: To investigate the correlation between cardiac output values and renal neutrophil gelatinase-associated lipocalin (NGAL) levels as a biomarker of renal ischemia.
Methods: Forty patients, who underwent off-pump coronary artery bypass (OPCAB) surgery and in whom the positioning of the heart was fixed with simple suspension sutures without a mechanical stabilizer, were included in the study. Continuous cardiac output (CO) measurements were recorded using the arterial pressure waveform analysis method (FloTrac sensor system) in the perioperative period. CO was recorded every minute during non-anatomical cardiac positioning for left anterior descending artery (LAD), diagonal artery (D), circumflex artery (Cx), and right coronary artery (RCA) bypasses. Serum NGAL samples were analyzed in the preoperative, perioperative, and postoperative periods.
Results: The CO values measured at various non-anatomical cardiac positions during distal anastomosis for LAD, D, Cx, and RCA were significantly lower than pre- and postoperative values measured with the heart in normal anatomical position (3.45±0.78, 2.9±0.71, 3.11±0.56, 3.19±0.81, 5.03±1.4, and 4.85±0.78, respectively, P=0.008). There was no significant difference between CO values measured at various non-anatomical cardiac positions during distal anastomosis. Although there was no significant correlation between NGAL levels and age, duration of surgery, preoperative CO, D-CO, RCA-CO, and postoperative CO measurements, there was a significant correlation between NGAL levels and LAD-CO (P=0.044) and Cx-CO (P=0.018) at the postoperative 12th hour.
Conclusion: Full revascularization may be achieved by employing the OPCAB technique while using simple suspension sutures without a mechanical stabilizer and by providing safe CO levels and low risk of renal ischemia.
Keywords: Coronary artery bypass, off-pump; Anastomosis, surgical; Coronary vessels; Arterial Pressure; Cardiac output; Biomarkers; Lipocalin-2; Longitudinal Studies
Heparin-coated vs. Non-coated Cardiopulmonary Bypass Circuits: Comparing Immediate Results with Different Target Activated Clotting Time

Muhammet Onur HanedanI; Mehmet Ali YürükI; Ali Kemal ArslanI; Aşkın KılıçI; Ufuk SayarI; İlker MataracıI

Braz J Cardiovasc Surg 35; Publish in: 8/2/2025
Objective: To compare immediate postoperative results in patients receiving heparin-albumin-coated and non-coated circuits.
Methods: A total of 241 patients undergoing on-pump cardiac surgery were divided into two groups: those receiving heparin-coated circuits (Bioline®, Maquet Cardiopulmonary AG., Hirrlingen, Germany) and those receiving non-coated circuits (Maquet Cardiopulmonary AG., Hirrlingen, Germany).
Results: Activated clotting times (ACT) during cardiopulmonary bypass (CPB) were significantly shorter in the heparin-albumin-coated group than in the non-coated group (355.64±34.12 vs. 560.38±90.20, respectively, P=0.001). In-hospital mortality and postoperative stroke rates and lengths of intensive care unit stay were similar between the groups; in contrast, in the heparin-albumin-coated group, patients had significantly better outcomes for hospital stay, drainage, and need for erythrocyte transfusion.
Conclusion: Heparin-coated circuits and reduced level of systemic heparinization with 300 seconds of target ACT level in cardiac surgery under CPB are safe and result in a very satisfactory clinical course.
Keywords: Cardiopulmonary bypass; Heparin; Hospital mortality; Length of stay; Erythrocyte transfusion; Silver; Cardiac surgical procedures; Intensive care units; Postoperative period
Surgical ‘Safari’ vs. Educational Program: Experience with International Cardiac Surgery Missions in Nigeria

Ikechukwu Andrew NwaforI; Aerra VickramIII; Kennedy O. OsenmoborIV

Braz J Cardiovasc Surg 35; Publish in: 8/2/2025
Introduction: In any country, the development and growth of open-heart surgery parallel stable political climate, economic growth, good leadership, and prudent fiscal management. These were lacking in Nigeria, which was under a military rule. The enthronement of democratic rule, in 1999, has caused desirable changes. The objective of this study is to report our experience with foreign cardiac teams that visited the National Cardiothoracic Center of Excellence, University of Nigeria Teaching Hospital, for seven years, in order to restart its open-heart surgery program.
Methods: To achieve the desired open-heart surgery training, our center received regular and frequent visits from foreign cardiac teams who would perform open-heart surgery with the local team.
Results: During the period of seven years, a total of 266 open-heart operations involving both adults and children were performed, with a mean of 38 cases per year; 150 (54.4%) males and 116 (43.6%) females were treated, with a ratio of 1.0:0.8. Six different teams visited the center at different periods.
Conclusion: After these years of cardiac missions to our center, the experience of the local team, especially the surgeons, is far from desirable because each team visit usually lasted about a week or two and each team, with exception of the CardioStart International/William Novick Global Cardiac Alliance, adopted the surgical ‘safari’ method.
Keywords: Military Personnel; Leadership; Nigeria; Economic Development; Surgeons; Hospital, Teaching; Cardiac surgical procedures; Growth and Development
Preoperative Arterial and Venous Cannulation in Redo Cardiac Surgery: From the Safety and Cost-effectiveness Points of View

Yahya YildizI; Mustafa Ozer UlukanII; Korhan ErkanlıII; Orcun UnalIII; Didem Melis OztasIV; Metin Onur BeyazII; Murat UgurlucanII

Braz J Cardiovasc Surg 35; Publish in: 8/2/2025
Objective: To investigate the safety and cost-effectiveness of preoperative cannulation and conventional approach techniques.
Methods: Sixty-one patients who underwent redo open cardiac procedures between September 2015 and November 2018 were divided into two groups - Group A (n: 30), patients who underwent conventional cannulation after sternotomy, and Group B (n: 31), those who underwent cannulation before sternotomy. Patients were evaluated retrospectively for general complication rates and total hospital costs.
Results: Mortality occurred in four patients from Group A and in one patient from Group B. Four patients required extracorporeal membrane oxygenation (ECMO) in Group A, whereas two required ECMO in Group B. Duration of total operation, cardiopulmonary bypass, and cross-clamp times were longer in the conventional surgery group than in the pre-sternotomy cannulation group (420.29±188.84 vs. 314.77±187.38, P=0.036; 171.87±85.59 vs. 141.7±82.47, P=0.089; and 102.94±70.67 vs. 60.97±52.81, P=0.009; respectively). Total blood and blood product usage were higher in Group A than in Group B. Postoperative intensive care unit stay was 62.77±145.3 hours vs. 25.13±73.11 hours, ventilation time was 5.16±5.09 hours vs. 3.03±2.78 hours, duration of ward stay was 5.23±2.52 days vs. 5.57±2.16 days, and duration of hospital stay was 9.58±5.85 days vs. 9.8±5.31 days in conventional sternotomy and pre-sternotomy cannulation groups, respectively. Total hospital costs were calculated 35863.52±20803.99 Turkish Liras (TL) in Group A and 25744.74±16472.03 TL in Group B (P=0,042).
Conclusion: Venous and arterial cannulations before sternotomy decreased myocardial injury and complication rates, blood and blood product usage, hospital stay, and, consequently, hospital costs in our modest cohort.
Keywords: Cardiopulmonary bypass; Extracorporeal membrane oxygenation; Sternotomy; Catheterization; Cost-Benefit Analysis
Comparison between Arch Zones in Modified Frozen Elephant Trunk Procedure for Complex Thoracic Aortic Diseases

Mustafa AkbulutI; Adnan AkI; Ozgur ArslanI; Arzu Antal DonmezI; Serpil TasI; Davut CekmeceliogluI; Mesut SismanogluI; Mehmet Altuğ TunçerI

Braz J Cardiovasc Surg 35; Publish in: 8/2/2025
Introduction: The aim of this study is to compare postoperative outcomes and follow-up of two different modifications facilitating surgical technique of frozen elephant trunk (FET) procedure for complex thoracic aortic diseases - zone 0 (fixation with total arch debranching) and zone 3 (fixation with islet-shape arch repair).
Methods: From May 2012 to December 2018, data were collected from 139 patients who had been treated with FET procedure for complex thoracic aortic diseases. According to Ishimaru arch map, patients with proximal anastomotic site of hybrid graft at zone 0 and zone 3 were grouped as Group A (n=58, 41.7%) and Group B (n=81, 58.3%), respectively. Mean age of study population was 54.7±11.4 years, and 111 patients were male (79.9%).
Results: In-hospital mortality was observed in 20 (14.4%) patients (n=12, acute type A aortic dissection, and n=4, previous aortic dissection surgery). There was no significant difference between both groups in terms of in-hospital mortality. Four patients from Group A and three patients from Group B had permanent neurological deficit (P=0.32). Three patients from both groups had transient spinal cord ischemia (P=0.334). Although mean total perfusion time was longer in Group A, duration of visceral ischemia, when compared with Group B, was shorter (P<0.001). Five-year survival rate was 82.8% in Group A and 81.5% in Group B (P=0.876).
Conclusion: FET procedure is a feasible repair technique in the treatment of complex aortic diseases, providing satisfactory early results. Because of its advantageous aspects, zone 0 fixation with debranching is the preferred technique in our clinic.
Keywords: Hospital mortality; Blood vessel prosthesis implantation; Survival rate; Follow-up studies; Aneurysm, dissecting; Aortic diseases; Spinal Cord Ischemia
Inspiratory Muscle Training Based on Anaerobic Threshold on the Functional Capacity of Patients After Coronary Artery Bypass Grafting: Clinical Trial

André Luiz Lisboa CordeiroI; Hayssa de Cássia MascarenhasI; Lucas LandersonII; Jaclene da Silva AraújoII; Daniel Lago BorgesIII; Thiago Araújo de MeloIV; André GuimarãesV; Jefferson PettoI

Braz J Cardiovasc Surg 35; Publish in: 8/2/2025
Introduction: Coronary artery bypass grafting (CABG) is associated with reduced ventilatory muscle strength and consequent worsening of functional capacity (FC). Inspiratory Muscle Training (IMT) can be indicated, but there is still a lack of knowledge about the use of the anaerobic threshold (AT) as a basis for prescription. The objective of this study is to evaluate if IMT based on AT modifies FC and inspiratory muscle strength of patients submitted to CABG.
Methods: This is a clinical trial. On the first postoperative day, the patients were divided into two groups: the conventional group (IMT-C), which performed IMT based on 40% of maximal inspiratory pressure (MIP), and the IMT-AT group, which performed IMT based on AT. All patients underwent preoperative and postoperative assessment of MIP and performed a six-minute walk test (6MWT).
Results: Forty-two patients were evaluated, 21 in each group. Their mean age was 61.4±10 years and 27 (64%) of them were male. There was a reduction of inspiratory muscle strength with a delta of 23±13 cmH2O in the IMT-C group vs. 11±10 cmH2O in the IMT-AT group (P<0.01) and of the walking distance with a delta of 94±34 meters in the IMT-C group vs. 57±30 meters in the IMT-AT group (P=0.04).
Conclusion: IMT based on AT minimized the loss of FC and inspiratory muscle strength of patients submitted to CABG.
Keywords: Muscular Strength; Myocardial Revascularization; Respiratory Muscles
Positive Heparin/PF4 Antibodies and High Mortality Rate: a Retrospective Case-Series Analysis

Mehmet EzelsoyI; Kemal Tolga SaracogluII; Kerem OralI; Ayten SaracogluIII; Belhan AkpinarI

Braz J Cardiovasc Surg 35; Publish in: 8/2/2025
Introduction: Heparin-induced thrombocytopenia (HIT) is a potentially lethal complication of unfractionated or low-molecular weight heparin therapy. We aimed to determine the incidence and mortality rate of patients with positive heparin/platelet factor 4 (PF4) antibodies, which is a rapid detection test of HIT.
Methods: Coronary artery bypass grafting and mitral and aortic valve surgeries were evaluated. Cardiopulmonary bypass was employed in all patients. The diagnosis of HIT was based on immunological assays. Postoperative complications, mortality rates, and the causes of death were specified in patients with positive heparin/PF4 antibodies.
Results: Postoperative thrombocytopenia was detected in 257 patients. Twenty of these patients undergoing open heart surgery were included in the final analysis. Antibodies against heparin/PF4 complex were positive in 20 patients. The mean body mass index was 28.8±2.3 kg/m2, mean value of left ventricular ejection fraction was 48.3±6.7%, cardiopulmonary bypass time was 113.0±35.0 min, aortic cross-clamping time was 88.0±32.7 min, mean intensive care unit length of stay was 10.9±4.9 days, mean preoperative platelet count was 307.250±88528 platelets/microliter, and mean postoperative platelet count was 243.050±89.354 platelets/microliter. The mean duration of heparin exposure was 6.9±2.9 days. The mortality rate was 45% (nine patients) and 1.2% (three patients) in heparin/PF4 complex positive and negative patients, respectively.
Conclusion: Although the incidence of HIT was low in patients undergoing open heart surgery, an increased rate of early mortality was observed in patients with positive heparin/PF4 antibodies.
Keywords: Thrombocytopenia; Heparin-adverse effects; Cardiopulmonary bypass; Aortic valve; Incidence; Cause of Death

SPECIAL ARTICLE

Rheumatic heart disease (RHD) remains the most common cardiovascular disease in young adults and adolescents in need of heart surgery in low- and middle-income countries (LMICs). The mean age of patients is 20-25 years, often much younger. By contrast, the few patients with chronic RHD in developed countries present a mean age of around 55 years. It is absolutely fundamental to differentiate these two types of population. Pathology, lesions and surgical methods are different, and the results should not be compared. It is not all the same!

A certain enthusiasm for mitral repair has recently surged, with several reports showing excellent results in children and young adults, resulting from the renewed interest of cardiac surgeons, also based on new and modified techniques developed in the meantime.

While surgery is easily accessible to patients in developed countries, the situation in LMICs is often dramatic, with countries where there is a complete absence of or few surgical facilities absolutely unable to meet gigantic demands. Many foreign surgical teams conduct humanitarian missions in several of these countries. They are just a “drop of water in the ocean” of needs. In some cases, however, these missions led to the establishment of local teams that now work independently and, in some cases, outperform the foreign teams still visiting.

Keywords: Rheumatic heart disease; Mitral Valve; Mitral Valve Repair; Developing Countries; Altruism

REVIEW ARTICLE
Saphenous Vein Vasa Vasorum as a Potential Target for Perivascular Fat-Derived Factors

Andrzej LoeschI; Michael Richard DashwoodII

Braz J Cardiovasc Surg 35; Publish in: 8/2/2025

Perivascular adipose tissue (PVAT) is a source of factors affecting vasomotor tone with the potential to play a role in the performance of saphenous vein (SV) bypass grafts. As these factors have been described as having constrictor or relaxant effects, they may be considered either beneficial or detrimental. The close proximity of PVAT to the adventitia provides an environment whereby adipose tissue-derived factors may affect the vasa vasorum, a microvascular network providing the vessel wall with oxygen and nutrients. Since medial ischaemia promotes aspects of graft occlusion the involvement of the PVAT/vasa vasorum axis in vein graft patency should be considered.

Keywords: Saphenous vein; Adventitia; Perivascular Fat; Vasa Vasorum; Microvessels; Nutrients
Hoarseness Due to Aortic Arch Aneurysms

Shi-Min YuanI

Braz J Cardiovasc Surg 35; Publish in: 8/2/2025
Objective: To give an overview of the Ortner’s syndrome caused by an aortic arch aneurysm.
Methods: By comprehensive retrieval of the pertinent literature published in the past two decades, 75 reports including 86 patients were collected and recruited into this study along with a recent case of our own.
Results: The aortic arch aneurysms causing hoarseness were most commonly mycotic aneurysms. In this patient setting, in addition to the left recurrent laryngeal nerve, trachea was the most commonly affected structure by the aortic arch aneurysm. Surgical/interventional/hybrid treatments led to a hoarseness-relieving rate of 64.3%, much higher than that of patients receiving conservative treatment. However, hoarseness recovery took longer time in the surgically treated patients than in the interventionally treated patients.
Conclusion: The surgical and interventional treatments offered similar hoarseness-relieving effects. Surgical or interventional treatment is warranted in such patients for both treatment of arch aneurysms and relief of hoarseness. Keywords: Hoarseness; Aneurysm, infected; Recurrent Laryngeal Nerve; Conservative Treatment; Trachea; Aorta Aneurysm
The Role of Thoracic Endovascular Aortic Repair (TEVAR) of Thoracic Aortic Diseases in Patients with Connective Tissue Disorders – A Literature Review

Amer HarkyI; Syed Mohammad Asim HussainI; Beverly MacCarthy-OfosuII; Mohammad Usman AhmadIII

Braz J Cardiovasc Surg 35; Publish in: 8/2/2025
Objective: To review the currently available literature to define the role of thoracic endovascular aortic repair (TEVAR) in patients with connective tissue disorders (CTD).
Methods: A comprehensive electronic database search was performed in PubMed, SCOPUS, Embase, Google scholar, and OVID to identify all the articles that reported on outcomes of utilizing TEVAR in patients with CTD during elective and emergency settings. The search was not limited to time or language of the published study.
Results: All the relevant studies have been summarized in its correspondence section. The outcomes were analyzed in narrative format. The role of TEVAR has been elaborated as per each study. Currently, there is limited large cohort size studies outlining the use of TEVAR in patients with CTD. The use of endovascular repair in patients with CTD is limited due to progressive aortic dilatations and high possibility of further reinterventions at later stage of life.
Conclusion: Open repair remains the gold standard method of intervention in young patients with progressive CTD, especially in the setting of acute type A aortic dissection. However, TEVAR can be sought as a reliable alternative in emergency setting of diseases involving the descending thoracic aorta; yet the long-term data needs to be published to support such practice. Keywords: Thoracic; Dilatation; Aneurysm; Dissecting; Aortic Diseases; Endovascular Procedures

BRIEF COMMUNICATION
Heterotopic Heart Transplantation as a Left Ventricular Biological Assistance: a New Two-Stage Method Proposal

Fábio Antonio GaiottoI; Antonio Carlos de Almeida BarbosaII; Davi Freitas TenórioI; Samuel Padovani SteffenI; Fabio B. JateneI

Braz J Cardiovasc Surg 35; Publish in: 8/2/2025

Since Barnard’s first heterotopic heart transplant in 1974, Copeland’s method has been the greatest contribution to heterotopic transplants but has the drawback of donor’s right ventricular atrophy. This new method proposes a modification in the anastomosis of the superior vena cava aiming to pre-serve donor’s right ventricular function by decompressing the pulmonary territory and reducing the pulmonary arterial pressure, as a biological ventricular assist device. Finally, a second intervention is proposed, where a “twist” is performed to place the donor’s heart in an orthotopic position after re-moval of the native heart. A pioneering research on this method received approval from the ethics committee of the Heart Institute of São Paulo. We believe that this method has the potential to im-prove quality of life in a selected group of patients.

Keywords: Heart-assist devices; Vena cava, superior; Ventricular Functional, Right; Quality of Life; Heart transplantation; Ethics Committees; Atrophy
Robotic Cardiac Surgery in Colombia: Overcoming the Challenges of a Middle-income Setting

Darío AndradeI; Eric E. VinckI; Juan F. ParraI; Husam H. BalkhyII; Federico NúñezI

Braz J Cardiovasc Surg 35; Publish in: 8/2/2025

In developing countries, limited resources and low health budgets result in slow developments in the field of cardiac surgery. As a consequence, advances in surgery become a challenging process. In Colombia, most institutions do not have the capacity or infrastructure for minimally invasive and video-assisted cardiac surgery, let alone robotic assisted cardiac surgery (RACS). Despite the challenges, efforts to overcome these hurdles are critical for the future of cardiac surgery in low-income settings. Here we describe the first cases of robotic cardiac surgeries performed in Colombia.

Keywords: Robotic Surgical Procedures; Robotics, Cardiac Surgical Procedures, Colombia; Health Resources, Poverty

HOW I DO IT
Mortality Rates of Surgical Techniques for Correcting Atrioventricular Disjunction

Élcio PiresI; Marcelo Luiz Peixoto SobralI

Braz J Cardiovasc Surg 35; Publish in: 8/2/2025

We compared the mortality rates of two surgical techniques for correction of atrioventricular disjunction in 10 out of 720 patients who underwent mitral valve replacement from 2005 to 2012. In group I, the mitral annulus was fixed with bovine pericardial strips; in group II, a 'patch' of bovine pericardium was sutured and extended from the base of the lateral and medial papillary muscles, covered the posterior wall of the left ventricle, went through the posterior mitral annulus, and ended in the posterior wall of the left atrium adjacent to the mitral ring. The group II technique showed a lower mortality.

Keywords: Mitral Valve; Heart ventricles; Papillary muscles; Pericardium; Heart atria; Pericardium; Tricuspid Valve
Left Atrial Appendage Thrombosis and Persistent Atrial Fibrillation: combined Treatment with a Totally Thoracoscopic Approach

Igor VendraminI; Andrea LechiancoleI; Luca RebellatoI; Ermanno DamettoII; Uberto BortolottiI; Ugolino LiviI

Braz J Cardiovasc Surg 35; Publish in: 8/2/2025

Minimally invasive surgical ablation is generally contraindicated in patients with atrial fibrillation and thrombosis of the left atrial appendage.

We have treated three of these patients using an innovative technique based on a bilateral video-thoracoscopic approach, performing a continuous encircling lesion at the pulmonary veins outflow with radio-frequency ablation, simultaneously excluding the left atrial appendage. The postoperative course was uneventful, without neurologic events and all patients maintained a stable sinus rhythm at 1-year follow-up.

This procedure represents a new mini-invasive method to treat persistent atrial fibrillation when partial thrombosis of the left atrial appendage contraindicates other ablation techniques.

Keywords: Pulmonary veins; Atrial Fibrilation; Atrial Appendage; Follow-up studies; Catheter ablation; Thromboembolism; Thrombosis; Longitudinal Studies

MULTIMEDIA
Coronary Artery Bypass Graft During the COVID-19 Pandemic

Lucas Molinari Veloso da SilveiraI; Gustavo Pampolha GuerreiroI; Luiz Augusto Ferreira LisboaI; Omar Asdrubal Vilca MejiaI; Luís Roberto Palma DallanI; Luís Alberto Oliveira DallanI; Fábio B JateneI

Braz J Cardiovasc Surg 35; Publish in: 8/2/2025

Since the beginning of the coronavirus disease (COVID-19) pandemic, in March 2020, the number of people infected with COVID-19 worldwide increases continuously. Brazil is being followed with great concern in the international media, as it can, very soon, be the epicenter of the pandemic. Initial surgical data suggest that patients who acquire COVID-19 in the perioperative period are prone to a higher morbidity and mortality, however, evidence in cardiac surgery is still scarce.

This article aims to aggregate to the growing evidence suggesting that perioperative infection with severe acute respiratory syndrome coronavirus 2 contributes to a more morbid evolution of the case.

Keywords: Cardiac surgical procedures; COVID-19; Coronavírus; Pandemia; SARS Virus; Perioperative Period

CASE REPORT
Conservative Treatment of Unicuspid Aortic Valve with Newly Diagnosed Type A Aortic Dissection

Vera GraupI; Lukas MeierII; Francesco MaisanoI; Ahmed OudaI

Braz J Cardiovasc Surg 35; Publish in: 8/2/2025

We present a case of a 36-year-old male patient with known arthrogryposis multiplex congenita and an associated unicuspid aortic valve. The patient later developed a significant aneurysm of the ascending aorta, however refused surgical intervention and missed follow-up appointments for 5 years. During an urgent, general practitioner-initiated transthoracic echocardiography followup, a chronic type A aortic dissection was diagnosed as a result of progressive aortic dilatation. Due to the stationary pressure gradients and non-progressive leaflet fibrosis, a conservative approach for to the unicuspid aortic valve was chosen, combined with replacement of the ascending aorta and partial replacement of the aortic arch.

Keywords: Aortic Valve Disease 1; Aortic valve; Aorta, thoracic; Dilatation; Heart valve diseases; Aortic diseases; Heart Defects, Congenital
Giant Left Atrium Associated with Massive Thrombus Formation 14 Years after Orthotopic Heart Transplantation

Krzysztof BartusI; Radoslaw LitwinowiczI; Boguslaw KapelakI; Grzegorz FilipI; Karol WierzbickiI; Randall J. LeeII

Braz J Cardiovasc Surg 35; Publish in: 8/2/2025

We report the case of a 60-year-old patient who underwent orthotopic heart transplant 14 years earlier. Routine echocardiography showed giant masses in the left atrium. There were no symptoms or thromboembolic events in the past. Magnetic resonance imaging study revealed very enlarged left atrium (8.7 × 10.6 cm) occupied by irregular smooth mass (7 × 5 × 6.1 cm) with a stalk that was attached to the posterior left atrial wall in the area of graft suture lines. Intraoperative examination revealed a massive thrombus (12 × 10 cm) that filled almost the entire left atrial area.

Keywords: Atrial Fibrilation; Heart atria; Thrombosis; Echocardiography; Thromboembolism; Heart transplantation; Magnetic Resonance Imaging; Sutures
Unusual Presentation of Patent Ductus Arteriosus in Elderly Patient

Slobodan V. MicovicI; Ivan M. NesicI; Miroslav D. MilicicI; Petar M. VukovicI

Braz J Cardiovasc Surg 35; Publish in: 8/2/2025

We presented a case of a 56-year-old man with giant pulmonary artery aneurysm caused by a misdiagnosed patent ductus arteriosus, severe multivalvular disease and active aortic valve endocarditis successfully treated by surgery. The correct diagnosis was missed despite preoperative diagnostics because the small patent ductus arteriosus was located at the distal part of common pulmonary trunk and a huge regurgitant signal overlapped its Doppler signal. Thorough evaluation of every patient, regardless of age, is necessary to recognize and treat this congenital anomaly.

Keywords: Patent ductus arteriosus; Adult Patient; Unusual Localization; Diagnostics
Late Cardiac Tamponade in a Patient Victim of Penetrating Trauma – Case Report

Adnaldo da Silveira MaiaI; Alexandre Bichara da CunhaII; Magnum Adriel Santos PereiraII; Natalia Pompeu ChavesIII; Ricardo Silva de MoraisIV; Lázaro Araújo de AlmeidaIV

Braz J Cardiovasc Surg 35; Publish in: 8/2/2025
Case Presentation: A case of a 49-year-old patient, male, victim of stab wound, developing belatedly cardiac tamponade and hemodynamic stability was reported. The patient underwent a pericardial window with drainage of pericardial effusion of blackened aspect; however, without visualization of the cardiac lesion, enlargement of the incision by median sternotomy was opted for. A hematoma was spotted at the left ventricle with epicardial lesion and a patch of pericardium was made with 3-0 polypropylene. The patient developed acute pulmonary edema and atrial fibrillation, which improved after the intensive care unit clinical management, with hospital discharge in the 7th postoperative day.
Keywords: Cardiac tamponade; Stab Wounds; Pericardial Window Techniques

MEMORY
A Tribute to Mauro Arruda - "A genius of surgery who will be remembered forever"

Ricardo C. LimaI; Mauro ArrudaII; Mozart A S EscobarII; José Ricardo LagrecaIV; José Lira MendesVI; José WanderleyVII; José Teles de MendonçaX

Braz J Cardiovasc Surg 35; Publish in: 8/2/2025

LETTER TO THE EDITOR
Myocardial Revascularization Surgery in COVID-19: Choosing the Most Opportune Moment for Intervention

Anderson da Rosa RosadoI; Franciele Kuhn MesacasaI; Leopoldo MoratelliI

Braz J Cardiovasc Surg 35; Publish in: 8/2/2025
The 3C’s: COVID-19, Children, and Cardiac Surgery – Do we know enough?

Sudhansoo KhannaI

Braz J Cardiovasc Surg 35; Publish in: 8/2/2025